32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

As a long-time fan of Grey’s Anatomy, I must say that the show never fails to surprise us with its unique and intriguing patient stories. From saving a deer’s life to a woman with independent pregnancies, each season offers a fresh dose of medical mysteries that keep us hooked.


As a dedicated gamer, I can confidently say that among the endless array of TV shows, Grey’s Anatomy on ABC stands out as an absolute legend. This medical drama has been running for what feels like eternity, and over this span, it’s tackled some truly bizarre medical cases – from rare diseases to mind-boggling injuries. And here’s a rundown of 32 of the most peculiar ones seen so far on this captivating series. Let’s dive in!

The principal actors in “Grey’s Anatomy” have successfully blended their characters’ personal stories with their roles as surgeons, making for a compelling mix that even the most squeamish fans can appreciate during the operation sequences. A significant aspect of the series, these medical cases often resonate with viewers and are frequently enhanced by iconic “Grey’s Anatomy” music. Below is a list of 32 bizarre injuries and illnesses encountered throughout the show’s broadcast history. Here they are, in no specific order:

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Man who swallowed doll heads.

In the initial phases of Grey’s Anatomy Season 2, a significant portion of the plot revolved around Addison joining Seattle and the shocking disclosure that McDreamy was already married. However, this period also featured some uniquely memorable patients, one being Mr. Hubbard, famously known as the Judy doll man. He presented to Seattle Grace with an intestinal blockage, traced back to consuming countless Judy doll heads. Definitely a peculiar case!

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Train crash victims who were stuck together.

In the past, catastrophic incidents like those portrayed on “Grey’s” were less frequent compared to current times. For instance, the train crash episodes from Season 2 stand as examples of such rarities. During these episodes, the characters were struggling to save Bonnie and Tom who had been impaled by the same metal pole. However, the surgeons soon discovered that it was only possible to rescue one of them, with Bonnie ultimately losing her life. Later, Bonnie appeared to Meredith in a vision during the ferry crash narrative.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The bomb in a man’s chest.

Christina Ricci is among several actors you may not immediately recall who graced the screens on “Grey’s Anatomy”, but she shines in a couple of highly-appreciated episodes. She portrays Hannah Davies, an EMT, who arrives at Seattle Grace with a patient’s hand inside her own chest. However, it is later disclosed that the gunshot wound was actually a live bomb that hadn’t detonated yet, causing the hospital to declare a Code Black and summoning a bomb squad for two hours of nerve-wracking TV drama.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Demi Lovato’s character can hear her own organs.

Demi Lovato made an appearance on an episode of “Grey’s Anatomy” during Season 6, just prior to the incident involving Meredith’s near-death experience due to a plane crash. Her character, Hayley May, initially seemed to be experiencing a mental health issue. However, it was later revealed that her condition was quite unusual. Alex uncovered a tiny perforation in her inner ear, which enabled Hayley to hear the functioning of her own organs and made her excessively sensitive to sound.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The man with a tree growing in his body.

In the seventh season of “Grey’s Anatomy,” a patient named Raul Arand appears. It isn’t long before Sandra Oh’s character, Cristina Yang, realizes that this man, who was initially thought to be in emotional turmoil, actually has a tree growing within his lung. This is an incredibly unusual situation, one that excites Cristina greatly.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The man whose twin was inside of him.

In the Season 10 episode titled “We Gotta Get Out of This Place,” we’re introduced to a character named Greg Penderglass. He expresses discomfort due to abdominal pain, and it’s later discovered that he has a rare condition known as fetus in fetu. This means he was carrying a twin while in the womb, which he unintentionally absorbed. Initially, being a collector of junk, he wants to keep this entity, but his feelings shift following surgery.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The man with a fish in his…

In Season 3 of Grey’s, the senior surgeons are competing for the Chief position when they learn about an important guest being admitted. This turns out to be Larry Jennings, a member of the Board, who found a fish lodged in an intimate area due to an unusual incident while on vacation. However, the most surprising revelation was that this happened during a skinny dipping excursion with his assistant, not his wife.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The guy who used porn as pain relief.

In the second season, I found myself cast as a patient, Henry Lamott, eagerly anticipating a spinal implant. My situation was dire, riddled with unbearable pain and an unfortunate allergy to most medications. In a bizarre twist, my doctor suggested watching adult content as a means of alleviating my agony. Incredulously, it seemed to work like a charm… that is, until the hospital experienced a power outage.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Mandy Moore’s character died for seemingly no reason.

Prior to appearing in This Is Us, Mandy Moore made some standout appearances on Grey’s Anatomy. She miraculously survived a harrowing shooting incident and, following a journey, underwent a colostomy bag reversal at Grey Sloan Memorial Hospital. The operation was successful, but she failed to regain consciousness after anesthesia and eventually succumbed when her organs suffered catastrophic failure. Tragically, the autopsy did not provide any answers regarding her sudden demise.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The prisoner who swallowed razor blades.

Constance Ferguson is an unconventional character introduced in Season 2 of “Grey’s Anatomy”. Rather than being a typical patient, she’s actually an inmate who intentionally ingested razor blades to be transported from prison to the hospital for treatment. After having surgery to remove the razor blades, she later needed a thoracotomy due to swallowing a lightbulb from her cell.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The lady who had spontaneous… pleasure

In Season 2, a character named Pamela Calva arrives at the hospital. She’s depicted as experiencing inexplicable, mature emotions, which are ultimately traced back to a tumor on her pudendal artery. Fortunately, she undergoes surgery and is subsequently able to live without the shame and fatigue associated with her condition.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Abigail Breslin’s character felt no pain.

In Season 3 of Grey’s Anatomy, a youthful Abigail Breslin portrays Megan Clover, a character who appears. She maintains that she was born with a special destiny as a superhero, given her inability to sense pain. Eventually, it is discovered that she has congenital insensitivity to pain with anhidrosis. To free herself from this “superpower,” she undergoes surgery.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The kid who was stuck in cement.

In Season 4, Grey’s Anatomy encountered some extraordinary medical scenarios, one of which involved a patient who ended up at Seattle Grace Mercy West Hospital after being enclosed in a cement block. Consequently, he sustained multiple injuries such as burns, fractured bones, crush wounds, and a pulmonary embolus. Fortunately, he was extracted from the cement and managed to pull through his close brush with death.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Exes who got stuck together via an IUD.

At the start of Season 3, a pair of patients, Sonya and Adam, arrive at the hospital following an unusual incident. They had become entangled while attempting to engage in a private moment, revealing their secret affair – a complicating factor being that they were once exes. The oddity of their predicament stemmed from Sonya’s IUD becoming ensnared in Adam’s body piercing, creating an intriguing medical conundrum.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Man whose body turns sugar into booze.

One of the more striking illnesses featured in the later years of Grey’s Anatomy’s extended television run is auto-brewery syndrome. In Season 15, a patient named Dave Buckley was hospitalized following an accident with a saw and a student from his workshop class. Initially mistaken for being intoxicated, he was eventually diagnosed with auto-brewery syndrome, a condition where the body converts sugar into alcohol.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The lady with a 70 pound tumor.

In the first season, we meet Annie Connors, a patient admitted at Seattle Grace, suffering from a massive tumor in her abdomen. Her reluctance to seek medical help stemmed from a deep-rooted fear of hospitals, as they had claimed several lives within her family. Tragically, she lost her life during the operation.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Woman with toxic blood.

In the captivating Season 3 episode titled “Wishin’ And Hopin'”, I found myself immersed in the interwoven stories of two engagements among the surgical team, but what truly left me spellbound was an extraordinary medical case that unfolded. Let me introduce you to Marina Rose Wagner, a patient under the care of my favorite character, Richard. An unusual turn of events occurred when her chemotherapy, in conjunction with an herbal supplement, transformed her blood into a potent neurotoxin. Unfortunately, this led her to unintentionally harm several surgeons before they could decipher the correct course of treatment for her.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Woman who grows bones out of any physical trauma.

In the third season, there was a patient named Cathy Rogerson who suffered from an uncommon disorder called fibrodysplasia ossificans progressiva. This peculiar condition causes bone growth in places where it shouldn’t, typically as a reaction to physical injury or impact. Consequently, she finds herself largely immobilized, with the exception of her hands and mouth.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The man who thinks he’s pregnant.

In Season 2 of “Grey’s Anatomy”, Shane Herman makes a brief appearance. His condition was a false pregnancy, later identified as mesenteric teratoma. Indeed, he appeared to be in a state of pregnancy.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Cristina is impaled by an icicle.

In the dual debut of Grey’s Season 5, Sandra Oh’s character Cristina Yang sustained an unusual wound of her own. After collapsing under the hospital, a massive icicle pierced her abdomen. Fortunately for her, Dr. Owen Hunt happened to be on hand to treat her emergency injury.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Law student who intentionally burned herself.

In a single episode of Season 3 of Grey’s Anatomy, we meet Gretchen, a law student who visits the hospital with a severe burn on her hand. It is later disclosed that she intentionally inflicted this injury to dodge taking the bar exam. Meredith eventually uncovers the truth and ensures her safety by having her admitted to the psychiatric ward.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Man who got mauled by a lion.

In Season 8, an individual named Paul, portrayed by actor-writer Danny Strong, is admitted to the hospital following bizarre events. More precisely, he was attacked by his girlfriend’s lion, which caused him extensive injuries, such as a tooth embedded within his body.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

He kid who looks like a lion.

As a devoted fan, I can’t help but reflect on the captivating journey of Jesse Plemons, who graced our screens as a guest star on Grey’s Anatomy before his meteoric rise to stardom. His character, Jake, was remarkable, living with craniodiaphyseal dysplasia, also known as ‘lionitis,’ which lent him an extraordinary visage due to his growths. Tragically, Jake’s life was cut short before Mark Sloan could perform the transformative surgery he had hoped for.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The man with a leg in the center of his body.

In the medical world portrayed on “Grey’s Anatomy”, a heated debate ensued among fans during Season 12, regarding a unique case involving Brian Carson. Diagnosed with osteosarcoma affecting his pelvis, spine, and sacrum, Brian was faced with an unconventional treatment – Callie performed a leg amputation to excise the cancerous bone, only to later re-attach it centrally on his body in an effort to preserve the limb.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Jane Doe’s facial injuries and amnesia.

In the third season, Karev rescued Rebecca Pope, who also went by Ava and Jane Doe, following the ferry boat accident. Her injuries were critical, with a disfigured face that made her unidentifiable and memory loss. However, her tale didn’t have a happy ending; despite being found by her husband, she struggled with psychosis and attempted suicide.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Millie Bobby Brown does surgery on her mother.

Back in the day, before I was a familiar face thanks to “Stranger Things,” I made an appearance in Season 11 of “Grey’s Anatomy.” When Seattle shook with an earthquake, my character Ruby found herself in a tight spot and had to undergo a home surgery guided by Owen Hunt. Looking back now, it seems obvious that the Upside Down didn’t stand a chance against such medical prowess!

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Izzie does saved a deer’s life.

In the opening episode of Season 4, the cherished initial team of interns (with George being excluded) are advanced to residents and are now in charge of a fresh batch of interns. Izzie’s inaugural day doesn’t proceed smoothly when a young boy implores her to treat an injured deer he brought to the emergency room. True to form, she takes on the challenge, much to the chagrin of the newly appointed surgeons.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The man with tree bark skin.

Jerry is a character on Grey’s Anatomy in its seventh season who has a severe case of HPV resulting in extensive warts that resembled tree bark on his hands. His health issue was particularly extreme, as a spider was found nesting within one of the warts during removal. Regrettably, his wife eventually found the situation intolerable and chose to leave him.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

The woman with independent pregnancies.

In Season 3, Noelle Lavette becomes Addison’s patient and is pregnant with twins. However, a later discovery reveals that she has a rare condition called uterus didelphys, which means she was born with two wombs. As a consequence, her “twins” were conceived from separate pregnancies, each fathered by different men.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Woman with a gun inside her privates.

In the television series ‘Grey’s Anatomy’, there have been some instances involving gunshots, but this particular one stands out as peculiar. A character named Danielle Gordon, who is a patient, sustains a gunshot wound in an unusual manner. It turns out that she was concealing a weapon intended for a prison transfer for her boyfriend, and the gun accidentally discharged… right inside her personal areas.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Cristina’s heart in a box.

As a devoted admirer, I can’t help but express my appreciation for Sandra Oh’s character, the phenomenal Cristina Yang on Grey’s Anatomy. Her unyielding demeanor and exceptional surgical skills have earned her a timeless place among the show’s beloved characters. In an unforgettable Season 8 moment, Cristina, alongside Teddy, performed a groundbreaking procedure – skillfully removing a donor heart and keeping it beating en route to LA with the help of a special box and device.

32 Weird Diseases And Injuries That Came Up On Grey’s Anatomy

Susan Grey dies from the hiccups.

Over seasons 2 and 3, I came across Susan Grey, Meredith’s stepmother who tied the knot with Thatcher as her second spouse. As our bond deepened, she found herself hospitalized due to relentless hiccups. Regrettably, upon being discharged, her health took a turn for the worse and she fell critically ill with sepsis and toxic megacolon with a perforation. Tragically, she succumbed to complications during surgery.

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2024-10-21 23:38